The expression of β-catenin, cyclinD1, and c-myc in the tumor tissues formed by the LGR5-knockdown HeLa and SiHa cells were markedly reduced compared with their controls (p<0.01), whereas expression in the tissues formed by the LGR5-overexpressing HeLa and SiHa cells were significantly increased compared with their controls (p<0.01). This evidence concerns the gene LGR5 and neoplasm.