LGR5 and neoplasm: To assess the effects of LGR5 expression in tumor formation, stable LGR5-knockdown cells (HeLa-shLGR5 and SiHa-shLGR5) and stable LGR5-overexpressing cells (SiHa-LGR5 and HeLa-LGR5) were established by shRNA and plasmid transfection.