In the present study, blockage with DKK-1, an inhibitor of Wnt/β-catenin signaling, resulted in a significant inhibition of the cervical cancer cell proliferation induced by LGR5 (Fig. 5), suggesting that LGR5 promotes cervical cancer cell proliferation via activation of the Wnt/β-catenin pathway. Here, LGR5 is linked to cervical cancer.