To further speculate the reason, we used three types of c-MET altered cancer cell lines including SNU-5, MKN-45, and SNU-638 gastric cancer cells (c-MET amplification), NCI-H596 non-small cell lung cancer (c-MET splice mutation) and HT-29 colon cancer cells (c-MET overexpression). The gene discussed is MET; the disease is malignant colon neoplasm.