The tumor burden as gauged by the number of disseminated tumor nodules was significantly fewer in mice injected with p70S6K (62.6% inhibition, P = 0.024), P-cadherin (73.5% inhibition, P = 0.047), and β1 integrin (54.2% inhibition, P = 0.021) shRNA-expressing spheroids. This evidence concerns the gene CDH3 and neoplasm.