AKT1 and atrial fibrillation: Phospho protein levels of Bcr-Abl and its downstream targets including Akt, Erk1/2 and STAT5 as well as total Bcr-Abl, STAT5 and Akt proteins were significantly decreased in the AF-treated tumors (Figure 6C), while the ubiquitinated proteins and IκB-α were greatly accumulated in AF-treated tumors compared with the control (Figures 6C and D).