As shown in Figure 2D, AF induced a remarkable decline in the expression of anti-apoptotic proteins, including Bcl-2, survivin, and XIAP in both KBM5 and KBM5-T315I cell lines, with less significant changes in the expression of Bcl-xL, Mcl-1 and Bax. The gene discussed is XIAP; the disease is atrial fibrillation.