EGFR and metastatic colorectal cancer: Even though survival for patients with unresectable metastatic colorectal cancer has improved over the past decade, due to the introduction of agents targeting the Epidermal Growth Factor Receptor (EGFR) and the Vascular Endothelial Growth Factor (VEGF), these treatments are often not curative, and intrinsic and acquired drug resistance is frequently observed in the clinical practice [2].