Analysis of expressed mutated surface genes revealed recurrent mutations in genes belonging to pathways known to be involved in colorectal cancer, including the WNT (LRP5 and FZD10), TGFβ (TGFBR3 and ACVR1B) and RTK-Ras (EGFR and ERBB3) signaling pathways [5]. This evidence concerns the gene LRP5 and colorectal cancer.