In addition to assessing the independent prognostic value of FOXP3+ TILs, adjusted by conventional clinicopathological confounding factors, we also investigated the prognostic effect of the interaction between regulatory and cytotoxic T-cell infiltrates (defined as CD8+ TILs) in different molecular subtypes of breast cancer, a novel analysis made possible by the large sample size and availability of concurrent biomarker data. The gene discussed is CD8A; the disease is breast carcinoma.