Although the Kaplan-Meier curves (Figure 1) showed that a high level of FOXP3+ iTILs (≥2) was significantly associated with worse BCSS in ER + breast cancer (P = 0.015), on multivariate Cox regression analysis the hazard ratio for FOXP3+ iTILs was not independently significant in this group (HR = 1.14, 95% CI = 0.96 to 1.37; P = 0.14), when adjusted for age, tumor grade, tumor size, nodal status, and lymphovascular invasion (Table 2). The gene discussed is FOXP3; the disease is breast cancer.