It is recommended to extend the immunohistochemical panel with other markers such as DOG1 and a mandatory study for KIT and PDGFRA mutation, being mindful that there is a small percentage of GIST with typical morphology, negative for CD117 and DOG1 and wild type for KIT and PDGFRA genotype [20]. Here, PDGFRA is linked to gastrointestinal stromal tumor.