LGR5 and colorectal carcinoma: In the present meta-analysis, through combining the outcomes of 6 published studies, comprising 1781 patients with CRC, we draw the conclusion that high LGR5 expression was significantly associated with poor OS (HR: 1.87, 95% CI: 1.23–2.84, P = 0.003), moreover, the high LGR5 expression was also significantly associated with worse DFS (HR: 2.44, 95% CI: 1.49–3.98, P<0.001) by combining the outcomes of 3 studies comprising 528 patients with CRC.