Four of the six variants are associated with reduced susceptibility to IPF and include SNPs in OBFC1, a gene involved in telomere maintenance, MAPT, the gene from which the microtubule-associated protein tau is produced [13], as well as the Toll interacting protein, TOLLIP, and signal peptidase, SPPL2C [10]. This evidence concerns the gene TOLLIP and idiopathic pulmonary fibrosis.