SELP and ischemic stroke: Larger platelets are metabolically and enzymatically more active than smaller platelets, containing more prothrombotic material such as thromboxane A2 and serotonin, and expressing greater numbers of adhesion molecules such as Glp IIb/IIIa receptor and P-selectin.11-14 They also show greater aggregation in response to ADP.10 Previous studies have shown that MPV was increased in myocardial infarction and ischaemic stroke, both of which are atherothrombotic events where platelets play a pivotal role.