TP53 and cervical carcinoma: On the other hand, P53 is mutated in 50% of carcinomas therefore miR-34a is down-regulated and its target p18Ink4c is increased in cervical cancer because the G1 check point is mutated most likely by the alteration of the feedback of miR-155-p53-miR-145, thereby overriding G1 checkpoint cell cycle.