SERPING1 and neuromyelitis optica: Fig. 4A shows that each of the three polysulfated macromolecules potentiated C1-inh inhibition of NMO-IgG-dependent CDC, reducing the C1-inh concentration needed to produce inhibition, by nearly 10-fold for heparin and dextran sulfate. Fig. 4B shows that each of the polysulfated macromolecules alone inhibited CDC, with substantial potentiation seen at a low concentration of C1-inh.