SERPING1 and neuromyelitis optica: Evaluation of C1-inh in NMO is motivated by its complement inhibition action on the serine protease activities of C1r and C1s in the classical complement pathway [25], [28], [29]; however, C1-inh inhibition of the complement lectin pathway has also been reported [41] and the serine protease inhibition action of C1-inh affects multiple other biological activities, including the coagulation system, the fibrinolytic system, T-lymphocyte activation and the kallikrein contact activation system [25], [26].