Since structural variants in genes such as MYC, MYCN and SOX2 are well described in SCLC [23], [24], our approach to generating PDX lines from EBUS-TBNA specimens could also serve as a platform for more intensive interrogation using WGS analysis to determine the effects of xenografting on chromosomal instability in SCLC. The gene discussed is SOX2; the disease is small cell lung carcinoma.