Circulating levels of total-, endogenous active MMP-9 and TIMP-1 were significantly higher in MetS subjects compared to non-Mets subjects (adjusted p<0.05, all), whereas levels of pro-MMP-9 and EMMPRIN were not (p = 0.15 and p = 0.64, respectively) (Table 3). Here, TIMP1 is linked to metabolic syndrome.