IFNL3 and infection: The association was slightly less significant in a multivariate model (OR = 0.60, 95% CI 0.35–0.99, P = 0.07), after adjustment for relevant covariates, including IFNL3 rs12979860 (OR = 0.35, 95% CI 0.24–0.49, P = 2.8E-9), male sex (OR = 0.76, 95% CI 0.53–1.07, P = 0.12), and infection by invasive procedure or needle stick (OR = 1.61, 95% CI 0.98–2.63, P<0.001), blood transfusion (OR = 2.91, 95% CI 1.81–4.66, P = 0.06), or through another risk (OR = 3.55, 95% CI 2.17–5.81, P<0.001), compared to drug use (Table 3).