CCR5 is expressed on many cell types, including Th1 cells [12] and hepatic stellate cells (HSCs) [13], [14], suggesting that this receptor may be important in viral clearance, response to therapy and fibrogenesis in chronic hepatitis C. Th1 response and increased CD8 T cell response via IFN-gamma production was associated with viral clearance and spontaneous recovery from acute HCV infection [15]. This evidence concerns the gene CCR5 and chronic hepatitis C virus infection.