IFNL3 and chronic hepatitis C virus infection: As already known, the latter are currently the strongest host genetic markers to predict IFN-alpha-based treatment-induced HCV clearance, and, as demonstrated in a recent and large serie of 813 Caucasian patients with chronic hepatitis C genotype 1 [27], CCR5delta32 did not improve prediction of SVR in the context of the IFNL3 polymorphisms.