A study [86] that performed flow cytometry-based whole-blood assays in 87 patients with unstable angina finds that beta-2 integrin mediated T-cell recruitment in coronary plaques identifies high-risk patients with severe coronary artery disease but no myocardial infarction and is predictive of future cardiovascular events, even in the absence of myocardium damage markers like troponin or high-sensitivity C-reactive protein. The gene discussed is ITGB2; the disease is angina unstable.