Fourneau et al. concede that the best human data exist for RHD and Guillain–Barre syndrome (GBS) but caution that even for RHD and GBS, it had not been demonstrated that the initial immune response to the target tissues in either disease is actually due to MM; it was quite possible that infection results in release of hidden antigens such as myosin and actin that add to, but do not induce, disease. The gene discussed is MYH14; the disease is rheumatic heart disease.