In all existing animal models of RHD and AM, even in susceptible strains of animals, the “causative” agents must always be accompanied by appropriate “adjuvants.” The M protein of GAS requires FCA (86); allogeneic myosin requires FCA (53, 87); CX requires either FCA boosted with pertussis or CX inoculated with cardiac alloantigens (28, 88, 89). This evidence concerns the gene MYH14 and rheumatic heart disease.