MYH14 and rheumatic heart disease: In addition, as Reddy et al. (42) has argued, if myosin were the major autoantigen inducing RHD and AM, then one would expect that patients with cardiac damage would develop these diseases at much higher rates than other patients, yet it has been demonstrated that patients who contract rheumatic fever or have cardiac infarcts, bypass surgeries, and heart transplants do not develop RHD or AM despite producing anti-myosin antibodies (43–46).