PI3K-AKT promotes cell survival by indirectly regulating the phosphorylation of various downstream signaling and target molecules including the mammalian forkhead box subgroup ‘O’ (FoxO) of forkhead transcription factors consists of FoxO1, FoxO3a, FoxO4 and FoxO6 which play an important role as tumor suppressor in several human malignancies. The gene discussed is FOXO3; the disease is neoplasm.