In contrast, Smurf2 was found to induce senescence and recent mouse model studies by Blank et al.[5] showed that Smurf2 is a bona fide tumor suppressor, as the Smurf2-deficient mice are prone to a variety of cancers, including lymphoma, hepatocellular, lung and mammary carcinoma. The gene discussed is SMURF2; the disease is breast carcinoma.