Combining PP13 with placental growth factor (PlGF) (156) or with additional biochemical markers [i.e. pregnancy associated plasma protein A (PAPP-A), PlGF and ADAM metallopeptidase domain 12 (ADAM12)] were also accompanied by an increased DR for preeclampsia in spite of the varying predictive values of the individual biomarkers (165). The gene discussed is PAPPA; the disease is preeclampsia.