However, a number of recent studies have reported that this drug has “non-cholinergic” effects on AD (Ratia et al., 2013; Huang et al., 2014) in addition to the symptomatic, cognitive-enhancing effect of cholinesterase inhibition (Wang et al., 1986; Liu and Liu, 1995; Zhu and Giacobini, 1995). The gene discussed is BCHE; the disease is Alzheimer disease.