FHL1 and myopathy: Although future studies of the autophagic flux in muscle cells from patients and animal models for FHL1 deficiency are needed in order to understand in detail how and to which extent deregulation of autophagy contributes to the pathogenesis of FHL1-related myopathies, our data demonstrate for the first time the coexistence of aggresomes and autophagy in the muscle biopsy of a patient with severe sarcopenia caused by p.C150R mutation in FHL1. These findings add new insights in delineating the altered mechanisms involved in the pathogenesis of FHL1-associated diseases.