MAPT and tauopathy: Numerous studies have demonstrated reduced hyperphosphorylation and aggregation of tau with alleviation of motor phenotype or axonal degeneration in murine models of tauopathy by inhibition of tau kinases such as GSK3β, PKA and PKC (Nakashima et al., 2005; Noble et al., 2005; Le Corre et al., 2006).