Other therapeutic avenues targeting toxic species may be even more specific; immunotherapy is a potential method for the removal of pathological tau, and in several instances has been demonstrated to suppress tau pathology and improve phenotype in transgenic models of tauopathy (Asuni et al., 2007; Sigurdsson, 2008; Yanamandra et al., 2013; Castillo-Carranza et al., 2014). This evidence concerns the gene MAPT and tauopathy.