PPARA and neuropathy: PPAR agonists have been shown, in animal neuropathy models, to possess neuroprotective (decreased lesion volume), anti-inflammatory (decreased microglial activation and inflammatory gene expression), antiapoptotic (decreased number of apoptotic neurons), antioxidative, and neurologically improving effects (Drew et al., 2005; Zhao et al., 2005; Racke et al., 2006; Park et al., 2007; Costa et al., 2008; Yi et al., 2008; Di Cesare Mannelli et al., 2013).