These mice show loss of nigral dopaminergic neurons, as is characteristically seen in PD, and develop Ub- and UCHL1-positive inclusions, although not Lewy Bodies, which are the histopathological hallmark of PD (Setsuie and Wada, 2007; Setsuie et al., 2007; Tan and Skipper, 2007). The gene discussed is UCHL1; the disease is Parkinson disease.