At day 3 of ICU treatment, the diagnostic value of presepsin (AUC = 0.84) to diagnose at least sepsis was significantly better than that of PCT (AUC = 0.69) (AUC difference, P = 0.05) and comparable to that of IL-6 (AUC = 0.81) (AUC difference, P >0.05). Here, IL6 is linked to Sepsis.