In addition, SIRT1 overexpression has been shown to correlate with poor prognosis in several cancer types, including large B-cell lymphoma (21), prostate cancer (18,22), pancreatic cancer (23), gastric cancer (24,25), breast cancer (26), hepatocellular carcinoma (27), colorectal cancer (28) and lung cancer (29). Here, SIRT1 is linked to prostate cancer.