ACHE and Alzheimer disease: Thus, current therapeutic approach for treating AD is the AChE inhibitors that increase the availability of ACh in the central cholinergic synapses, such as donepezil, rivastigmine, and galantamine (Terry and Buccafusco 2003), as well as acting on the glutamatergic system by blocking NMDA-type glutamate receptors (memantine) (Rountree et al. 2009).