RPS24 and Diamond-Blackfan anemia: Interestingly, RPS24-deficient cells showed increased levels of the cell cycle inhibitor p21 and a seemingly opposing increase in Cyclin-E, CDK4 and CDK6. The exact mechanism of DBA may be a combined effect of ribosome synthesis and p53 activation, and more efforts are needed to correlate specific mutations to the disease phenotypes such as its impact on erythropoiesis.