CDH1 and in situ carcinoma: The epithelial marker E-cadherin was expressed at high levels in the glandular epithelium of H. E-cadherin staining intensity was lower in most CIS (SI: 0 to 3, median was 2) samples than in H (SI: 2 to 4, median was 3) samples (P = 0.008), and it was higher in A (SI: 0 to 4, median was 3) than in CIS (P = 0.827).