[31], [32]. In conclusion, neither the function nor the source of sRAGE in human physiology is known. Expression profiling for esRAGE in multiple human organs and RAGE in human thymus has recently been performed [33], [34]. Plasma/serum concentrations of sRAGE in diabetes mellitus type 2 and coronary artery disease have been studied with conflicting findings [35], [36]. This evidence concerns the gene AGER and diabetes mellitus.