The current view that RAGE - RAGE-ligand interaction augments pro-inflammatory pathways is supported by the detection of RAGE and RAGE ligands in tissues of various disease processes, such as arteriosclerosis [18], diabetes [23], glomerulosclerosis [24], periodontal disease [25], arthritis [26], transplantation [27] and other chronic inflammatory disorders. Here, AGER is linked to arthritic joint disease.