Interestingly, Pilon et al. reported that SR-BI expression is increased in human adrenocortical cells in response to PKC activators, resulting in higher lipoprotein binding and specific cholesteryl ester uptake utilized for steroidogenesis [129], and we have previously reported that activation of PKC in transfected Chinese hamster ovary-derived and in HepG2 human hepatoma cells modulates the activity of SR-BI [37], [39]. The gene discussed is PRRT2; the disease is hepatocellular carcinoma.