DYRK1A and Dravet syndrome: To evaluate the role of Dyrk1A in the cognitive function of TS mice and in the various mechanisms proposed to underlie these phenotypic alterations, in this study, we genetically normalized the Dyrk1A gene dosage in the TS mouse and demonstrated that the overexpression of this gene is involved in working and reference memory, contextual fear conditioning and hippocampal LTP and neuromorphological (cell proliferation and differentiation in the DG, as well as the density of GABAergic and glutamatergic synapse markers) abnormalities found in the hippocampus of this model of DS.