Additional support for the role of Dyrk1A in the altered cognitive abilities found in DS mouse models comes from studies demonstrating that the pharmacological inhibition of this gene using epigallocatechin gallate (EGCG), improves hippocampal-dependent learning and thigmotaxis in TgDyrk1A and Ts65Dn mice [11], [61]. The gene discussed is DYRK1A; the disease is Dravet syndrome.