CDKN2A and neoplasm: However, overexpression of p16INK4a was not significantly associated with tumor TNM staging (I+II vs. III+IV) (OR = 0.75, 95% CI: 0.35–1.63, P = 0.47) (Fig. 2B), the tumor grade (G1+ G2 vs. G3) (OR = 0.78, 95% CI: 0.39–1.57, P = 0.49)(Fig. 2C), the tumor size (<4 vs. ≥4 cm) (OR = 1.10, 95% CI: 0.45–2.69, P = 0.83) (Fig. 2D), or vascular invasion (OR = 1.20, 95% CI: 0.69–2.08, P = 0.52) (Fig. 2E).