With this in mind, in the present work we studied a group of subjects carrying GRN Thr272fs mutation (FTD patients and still asymptomatic subjects in order to evaluate: 1) the functional connectivity alterations in the different disease stages, from preclinical to symptomatic phases; 2) the effect of age on GRN related pathology, in order to trace progressive brain damage during disease course. This evidence concerns the gene GRN and frontotemporal dementia.