Furthermore, looking at the increased functional connectivity in frontal regions, a potential compensatory mechanism cannot be excluded a priori[54], [69], as previously reported by our group [16].When disease progresses, as demonstrated by data obtained in FTD carrying GRN mutation and by regression analysis with age, more anterior regions, i.e. frontal lobes, are also involved. The gene discussed is GRN; the disease is frontotemporal dementia.