NSD2 and plasma cell myeloma: To test whether MMSET reduction can inhibit myeloma growth in vivo, we injected the flanks of NOD/SCID mice with t(4;14)+ KMS11 cells expressing a doxycycline-inducible shRNA targeting MMSET. We previously demonstrated that expression of this shRNA decreases MMSET and H3K36me2 levels, increases H3K27me3 levels and leads to cell growth arrest [12].