We performed double immunostaining of GFAP and L-DOPA in the striatal sections of hemi-PD models that were repeatedly injected with L-DOPA/carbidopa (50/5 mg/kg/day, i.p.)for 7 days, and co-localization of both signals were analyzed by confocal laser-scanning microscopy. This evidence concerns the gene GFAP and Parkinson disease.