Therefore, since TLR3 and TLR4 molecules contribute to the generation of a normal IFN response through activation of IRF-3, IRF-5, and IRF-7 after infection with neurotrophic virus [14], [15], we tested whether the ablation of TLR3 and TLR4 molecules affected type I innate responses in JEV infection. Here, IRF7 is linked to infection.