To this end, we assessed the impact of each TLR molecule on JE, by evaluating the susceptibility of TLR2−/−, TLR3−/−, TLR4−/−, TLR7−/−, and TLR9−/− mice to JEV infection (1.4×107 pfu) (Figure S1). Here, TLR4 is linked to Japanese encephalitis.