APOE and atherosclerosis: Treatment with CGA significantly reduced the serum concentration of proinflammatory cytokines closely related with the development and progress of atherosclerosis such as IL-6, IL-8, TNFα and MCP-1 [39] (Figure 3) in ApoE−/− mice and decreased the intracellular levels of IL-1β, IL-6 and TNFα in LPS-elicited RAW264.7 cells (Figure 4), indicating a potent antiinflammatory activity as previously reported [31], [40].