When Dullaartet al.13 meta-analyzed data on theTaq1B SNP (rs708272) from population-based and high-risk groups separately, the odds ratio for cardiovascular disease (CVD) in homozygotes for theB2 allele (who have low CETP activity) was 0.84 in the high-risk subjects, but 1.45 in the population-based samples. The gene discussed is CETP; the disease is cardiovascular disorder.