In the study, the human basophil degranulation test (HBDT), which assumes that the degranulation of basophils in the presence of a specific allergen is an index of an IgE-dependent cellular response, was tested on 46 unselected patients with INS (28 with MCNS and 18 with focal segmental glomerular sclerosis) with or without atopic manifestations. This evidence concerns the gene IGHE and lipoid nephrosis.