Furthermore, since clinical manifestations are usually caused by a combination of bacteremia and enodoxemia in a more chronic manner (Hurley, 1995), we tested the protective effect of NEU1 inhibitor for infection with endotoxin-producing Escherichia coli. As shown in Figure 5F, Neu5Gc2en protected mice against lethal E. coli (strain 25922) infection. Here, NEU1 is linked to bacterial infectious disease with sepsis.