TYROBP and Nasu-Hakola disease: Mutations in TREM-2 and DAP12 cause sclerotic lesions in the white matter of the central nervous system (CNS) in human polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)/Nasu-Hakola disease [39,40] and cause hypomyelinosis in mice [41].