Therefore, down-regulated NAP1L2 would be consistent with the idea that neurodegeneration may additionally result from loss of essential regions of euchromatin, secondary to dysregulation of neuron-specific epigenetic regulators such as NAP1L2. If true, loss of NAP1L2 could help to explain the diverse panel of down-regulated neuron-specific genes across neurodegenerative diseases. The gene discussed is NAP1L2; the disease is neurodegenerative disease.