Additional hub proteins included CDK5, CALM1 (part of the calmodulin protein complex), and BCL6. While aberrant CDK5 and calmodulin activity have been associated with neurodegenerative diseases through tau hyperphosphorylation and calcium signaling respectively [57],[60], BCL6 has not been previously associated with neurodegeneration. This evidence concerns the gene MAPT and neurodegenerative disease.