Multiple studies have highlighted the inflammation-driving role of MK2 and MK3 (reviewed in [43]) by showing that mice deficient for one or more of these kinases are protected against diverse inflammatory conditions, including arthritis, pancreatitis, skin inflammation, acute proliferative glomerulonephritis, colitis, cardiac ischemia-reperfusion injury [44], and asthma [41] or ventilator-induced [45] lung injury. This evidence concerns the gene MAPKAPK2 and arthritic joint disease.