These factors play key roles in regulating tumor cell proliferation, survival and malignancy through the activation of diverse signaling pathways, including the Smad, PI3K, Jak/Stat, NF-κB, MAPK, CXCR2 and IL-1 network (Nguyen et al., 2009; Ohanna et al., 2011; Coppé et al., 2011). This evidence concerns the gene NFKB1 and neoplasm.