IL6 and neoplasm: fibroblast or epithelium; Fourth, multiple DDSP proteins are well-known to promote disease evolution particularly tumor progression, including proteases (MMPs), growth factors (AREG, EREG), pro-angiogenic factors (ANGPTL4, VEGF), and pro-inflammatory cytokines (IL-6, IL-8) (Coppe et al., 2008; Kuilman et al., 2008; Sun et al., 2012).