Poly (ADP-ribose) polymerase 1 (PARP-1) detects DNA lesions and promotes DNA repair, but can also mediate NF-κB activation upon genotoxic stress, as suppression of NF-κB activity and CCL2 secretion by the PARP-1 inhibitor 3-AB diminishes a secretome in senescent melanoma cells (Ohanna et al., 2011). This evidence concerns the gene NFKB1 and melanoma.