As part of the acute secretory responses that occur in certain contexts, cytokines including IL-6 and Timp-1 are released in thymus after DNA damage, thereby creating a “chemoresistant milieu” that promotes the survival of a minimal residual tumor burden via protecting lymphoma cells from demise induced by doxorubicin (Gilbert and Hemann, 2010). The gene discussed is TIMP1; the disease is lymphoma.