TNFRSF11B and rheumatoid arthritis: In this regard, even if no association was observed between allelic and genotypic OPG variants and CV disease (not shown), in the haplotype analysis, a protective effect of the CGA haplotype on the risk of CV disease after adjusting for sex, age at RA diagnosis and traditional CV risk factors was disclosed in the group of anti-CCP negative RA patients (HR = 0.54; 95% CI: 0.31–0.95; p = 0.032) (Table 2).