In the present study, we show that the CHA2DS2-VASc score reliably predicts a short-term, 30-day unfavourable outcome of AIS (regardless of the presence or absence of AF), and that adding the high-sensitivity TnI (or fibrinogen or CRP, or all three biomarkers) to CHA2DS2-VASc score does not further improve the prediction. Here, CRP is linked to atrial fibrillation.