12 Tsukumo Tsukumo DM DM Carvalho Carvalho MA MA Filho Filho Carvalheira Carvalheira JB JB Prada Prada PO PO Hirabara Hirabara SM SM Schenka Schenka AA AA et al. et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. This evidence concerns the gene TLR4 and obesity disorder.