Experimental model of pulmonary emphysema is based on nebulization or instillation of proteolytic enzyme, such as panain (Carica papaya),(7) porcine pancreatic elastase,(4) and human neutrophil elastase.(8) This proteolytic process, associated with uniform destruction of ECM of pulmonary acinus, ends up in morphohistological and physiological changes in lungs that resemble those changes find in emphysema in humans.(9,10). The gene discussed is ELANE; the disease is pulmonary emphysema.