The rs10865331 polymorphism located 99 kb upstream of B3GNT2 and 182 kb downstream of TMEM17. Although the mechanism and functions leading to progression of AS still need to be elucidated, an SNP on B3GNT2 was found to be a susceptibility marker for rheumatoid arthritis in a Japanese GWAS meta-analysis [21]. This evidence concerns the gene TMEM17 and rheumatoid arthritis.